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IgG4-related disease has been described as an indolent condition. Although possibly based on opinion rather than on objective assessments, symptoms, if any, are commonly described as mild in the medical literature. [7] This can be in spite of considerable underlying organ destruction.
IgG4-RD: IgG4-related disease: IgG4-RKD: IgG4-related kidney disease IgG4-ROD: IgG4-related ophthalmic disease: IgG4-TIN: IgG4-related tubulointerstitial nephritis IgM: immunoglobulin M: IGT: impaired glucose tolerance: IHC: immunohistochemistry: IHD: ischaemic heart disease: IHPS: infantile hypertrophic pyloric stenosis IHSS
IgG deficiency is a form of dysgammaglobulinemia where the proportional levels of the IgG isotype are reduced relative to other immunoglobulin isotypes.. IgG deficiency is often found in children as transient hypogammaglobulinemia of infancy, which may occur with or without additional decreases in IgA or IgM.
The water-accessible surface area of an IgG antibody. Immunoglobulin G (IgG) is a type of antibody.Representing approximately 75% of serum antibodies in humans, IgG is the most common type of antibody found in blood circulation. [1]
The diagnosis of IgG4-related prostatitis could be made from histological examination if prostate biopsy or surgery has been performed. [6] The hallmark histopathological features of established IgG4-related disease are storiform fibrosis, a dense lymphoplasmacytic (lymphocytes and plasma cells) infiltrate rich in IgG4-positive plasma cells, and obliterative phlebitis.
Sortable table Abbreviation Meaning Δ: diagnosis; change: ΔΔ: differential diagnosis (the list of possible diagnoses, and the effort to narrow that list) +ve: positive (as in the result of a test)
Although a clear understanding of the various skin lesions in IgG4-related disease is a work in progress, skin lesions have been classified into subtypes based on documented cases: [2] Angiolymphoid hyperplasia with eosinophilia (or lesions that mimic it) [3] and cutaneous pseudolymphoma; Cutaneous plasmacytosis [Note 1]
IgG4-related ophthalmic disease (IgG4-ROD) is the recommended term to describe orbital (eye socket) manifestations of the systemic condition IgG4-related disease, [2] which is characterised by infiltration of lymphocytes and plasma cells and subsequent fibrosis in involved structures. It can involve one or more of the orbital structures.