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5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine), also known as O-methylbufotenin or mebufotenin (INN Tooltip International Nonproprietary Name), is a naturally occurring psychedelic of the tryptamine family. [5] [1] [4] [2] It is found in a wide variety of plant species, and is also secreted by the glands of at least one toad species, the Colorado ...
5-Methoxy-α,N,N-trimethyltryptamine (5-MeO-α,N,N-TMT), also known as α,N,N,O-tetramethylserotonin (α,N,N,O-TMS), is a little-known synthetic substituted tryptamine and the combined derivative of 5-MeO-DMT and α-methyltryptamine (αMT or AMT).
[3] [5] [6] On the other hand, 5-MeO-isoDMT has comparable psychoplastogenic potency and effects compared to the psychedelic 5-MeO-DMT. [1] [2] [4] [5] These effects are blocked by the serotonin 5-HT 2A receptor antagonist ketanserin. [4] [5] Certain analogues and derivatives of 5-MeO-isoDMT, like isoDMT and the α-methylated AAZ-A-154 (DLX-001 ...
5-MeO-DMT is a potent and fast-acting psychedelic, which is naturally produced by the Sonoran Desert toad as well as some species of plants. Its short duration –from 20 minutes to one hour– is ...
[1] [2] Several existing psychoplastogens have been identified and their therapeutic effects demonstrated; several are presently at various stages of development as medications including ketamine, MDMA, scopolamine, and the serotonergic psychedelics, including LSD, psilocin (the active metabolite of psilocybin), DMT, and 5-MeO-DMT.
DMT is found as a minor alkaloid in snuff made from Virola bark resin in which 5-MeO-DMT is the main active alkaloid. [14] DMT is also found as a minor alkaloid in bark, pods, and beans of Anadenanthera peregrina and Anadenanthera colubrina used to make Yopo and Vilca snuff, in which bufotenin is the main active alkaloid.
However, the non-hallucinogenic nature of 6-MeO-DMT has yet to be confirmed in humans. [6] [2] In addition to its apparent lack of hallucinogenicity, 6-MeO-DMT shows dramatically reduced potency as an agonist of all of the serotonin receptors compared to 5-MeO-DMT. [4] 6-MeO-DMT was first described in the scientific literature by 1968.
It is the 5-methyl thio analog of dimethyltryptamine (DMT). 5-MeS-DMT was first synthesized by Alexander Shulgin. In his book TiHKAL (Tryptamines I Have Known and Loved), the minimum dosage is listed as 15-30 mg. [1] The duration listed as very short (less than one hour), just like DMT. 5-MeS-DMT produces similar effects to DMT, but weaker.