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It is a protein that in humans is encoded by gene ABCC11. [3] [4] [5] The gene is responsible for determination of human cerumen type (wet or dry ear wax) and presence of underarm osmidrosis (odor associated with sweat caused by apocrine secretion), and is associated with colostrum secretion. [6]
The ABCC11 gene determines axillary body odor and the type of earwax. [ 6 ] [ 31 ] [ 32 ] [ 33 ] The loss of a functional ABCC11 gene is caused by a 538G>A single-nucleotide polymorphism , resulting in a loss of body odor in people who are specifically homozygous for it.
Body odor encompasses axillary (underarm) odor and foot odor. [1] It is caused by a combination of sweat gland secretions and normal skin microflora. [1] In addition, androstane steroids and the ABCC11 transporter are essential for most axillary odor. [1] [2] Body odor is a complex phenomenon, with numerous compounds and catalysts involved in ...
According to experts, there’s actually a gene mutation behind it. Between 80 and 95% of East Asians have a dysfunction of the ABCCII gene, which is linked to smelly pits, a number of studies say.
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Own work inspired by T. Ishikawa, Y. Toyoda et al.: Pharmacogenetics of human ABC transporter ABCC11: new insights into apocrine gland growth and metabolite secretion. In: Frontiers in genetics. Vol. 3, 2012, Article 306, ISSN 1664-8021. PMID 23316210. PMC 3539816: Author: Kuebi = Armin Kübelbeck: SVG development
Joan Collins has legs for days!. After the Dynasty actress, 91, shared a carousel of photos from her and husband Percy Gibson's recent vacation in Cancun, Mexico, via Instagram, fans couldn't help ...
This distinction is caused by a single base change in the "ATP-binding cassette C11 gene". Dry-type individuals are homozygous for adenine (AA) whereas wet-type requires at least one guanine (AG or GG). [6] Dry earwax is gray or tan and brittle, and is about 20% lipid. [5] It has a smaller concentration of lipid and pigment granules than wet ...