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The DNA repair function of alpha-synuclein appears to be compromised in Lewy body inclusion bearing neurons, and this may trigger cell death. Study of synucleinopathy mouse models of Parkinson's disease indicates that alpha-synuclein pathogenesis is associated with increased DNA damage and activation of the DNA damage response. [19]
A Lewy body is composed of the protein α-synuclein associated with other proteins, such as ubiquitin, [9] neurofilament protein, and alpha B crystallin. Tau proteins may also be present, and Lewy bodies may occasionally be surrounded by neurofibrillary tangles .
Dementia with Lewy bodies and Parkinson's disease dementia are similar in many ways, suggesting there may be a common pathophysiological mechanism, with PDD and DLB at opposite ends of a Lewy body disease spectrum, [2] and a shared component of protein deposits in Lewy bodies and Lewy neurites. [17]
Other types of dementia that affect those over 65 include Lewy body dementia, brought on by abnormal deposits of the protein alpha-synuclein known as Lewy bodies, vascular dementia, created by ...
Also known as Lewy body dementia, it is caused by clumps of protein in the brain called Lewy bodies. People with dementia with Lewy bodies share many of the same symptoms of Alzheimer’s disease ...
Two 1997 discoveries highlighted the importance of Lewy body inclusions in neurodegenerative processes: a mutation in the SNCA gene that encodes the alpha-synuclein protein was found in kindreds with Parkinson's disease, and Lewy bodies and neurites were found to be immunoreactive for alpha-synuclein. [234]
Lewy Body Dementia (LBD) is the second-most common form of dementia after Alzheimer’s disease; However, unlike most well-known forms of dementia, LBD isn’t characterized by memory loss.
Alpha-synuclein is the primary structural component of Lewy body fibrils. Occasionally, Lewy bodies contain tau protein; [100] however, alpha-synuclein and tau constitute two distinctive subsets of filaments in the same inclusion bodies. [101] Alpha-synuclein pathology is also found in both sporadic and familial cases with Alzheimer's disease ...
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