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Metabolic intermediates are compounds produced during the conversion of substrates (starting molecules) into final products in biochemical reactions within cells. [1]Although these intermediates are of relatively minor direct importance to cellular function, they can play important roles in the allosteric regulation of enzymes, glycolysis, the citric acid cycle, and amino acid synthesis.
In biochemistry, a metabolite is an intermediate or end product of metabolism. [1] The term is usually used for small molecules.Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g. pigments, odorants, and ...
Edson made contributions to knowledge of cellular intermediary metabolism; developed a system of education in the elements of biochemistry for students of medicine, dentistry, and home science; a programme for a training in biochemistry leading to BSc/MSc; supervised postgraduate students in biochemistry to PhD; and was the medical member of ...
With Paul K. Stumpf, Conn co-founded the department of biochemistry and biophysics at Davis and taught an introductory course in biochemistry until his retirement in 1993. Conn researched phenylalanine ammonia-lyase and cyanogenic glycosides. Notable students include the plant biochemist and phytopathologist Tsune Kosuge.
Schoenheimer's scientific work contributed to biochemistry and metabolic studies, with his most significant work being the application of isotopes to the study of intermediary metabolism. Schoenheimer's earlier scientific work in the 1920s centered on the physiology and pathology of sterols .
Rittenberg's doctoral work concerned thermodynamic properties of molecules containing 2 H (deuterium), [2] and he built his career principally on work with isotopes. [3]His introduction of the use of 2 H [4] as a tracer to follow the fate of various different compounds in human metabolism changed the prevailing scientific theory, from a static, "wear and tear" view of metabolic processes, to a ...
The TCA cycle is a hub of metabolism, with central importance in both energy production and biosynthesis. Therefore, it is crucial for the cell to regulate concentrations of TCA cycle metabolites in the mitochondria. Anaplerotic flux must balance cataplerotic flux in order to retain homeostasis of cellular metabolism. [1]
Chloragogen cells, also called y cells, are star-shaped cells in annelids involved with excretory functions and intermediary metabolism. These cells function similar to the liver found in vertebrates. Chloragogen tissue is most extensively studied in earthworms. [1]