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Metabolic intermediates are compounds produced during the conversion of substrates (starting molecules) into final products in biochemical reactions within cells. [1]Although these intermediates are of relatively minor direct importance to cellular function, they can play important roles in the allosteric regulation of enzymes, glycolysis, the citric acid cycle, and amino acid synthesis.
In biochemistry, a metabolite is an intermediate or end product of metabolism. [1] The term is usually used for small molecules.Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g. pigments, odorants, and ...
Edson made contributions to knowledge of cellular intermediary metabolism; developed a system of education in the elements of biochemistry for students of medicine, dentistry, and home science; a programme for a training in biochemistry leading to BSc/MSc; supervised postgraduate students in biochemistry to PhD; and was the medical member of ...
Schoenheimer's scientific work contributed to biochemistry and metabolic studies, with his most significant work being the application of isotopes to the study of intermediary metabolism. Schoenheimer's earlier scientific work in the 1920s centered on the physiology and pathology of sterols .
Chloragogen cells, also called y cells, are star-shaped cells in annelids involved with excretory functions and intermediary metabolism. These cells function similar to the liver found in vertebrates. Chloragogen tissue is most extensively studied in earthworms. [1]
With Paul K. Stumpf, Conn co-founded the department of biochemistry and biophysics at Davis and taught an introductory course in biochemistry until his retirement in 1993. Conn researched phenylalanine ammonia-lyase and cyanogenic glycosides. Notable students include the plant biochemist and phytopathologist Tsune Kosuge.
In land-dwelling animals, it is an intermediary metabolite in nitrogen disposal through the urea cycle and the synthesis of pyrimidines. Its enzymatic counterpart, carbamoyl phosphate synthetase I (CPS I), interacts with a class of molecules called sirtuins, NAD dependent protein deacetylases, and ATP to form carbamoyl phosphate.
Metabolite pool is a collective term for all of the substances involved in the metabolic process in a biological system.Metabolic pools are within cells (or organelles such as chloroplasts) and refer to the reservoir of molecules upon which enzymes can operate.