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October 2000 UK (Invicorp): aviptadil, in combination with the adrenergic drug phentolamine, is approved as an effective alternative therapy for erectile dysfunction (ED) patients. One dose intracavernosal injection contains 25 micrograms aviptadil and 2 mg of phentolamine mesilate for the treatment of ED.
The primary application for phentolamine is for the control of hypertensive emergencies, most notably due to pheochromocytoma. [5]It also has usefulness in the treatment of cocaine-induced cardiovascular complications, where one would generally avoid β-blockers (e.g. metoprolol), as they can cause unopposed α-adrenergic mediated coronary vasoconstriction, worsening myocardial ischemia and ...
Nonselective alpha blockers, such as phenoxybenzamine or phentolamine, can be used to mitigate this disease. Pheochromocytoma is a disease in which a catecholamine secreting tumor develops. [ 2 ] [ 20 ] Specifically, norepinephrine and epinephrine are secreted by these tumors, either continuously or intermittently. [ 21 ]
Phenoxybenzamine is used as an anti-hypertensive due to its efficacy in reducing the vasoconstriction caused by epinephrine (adrenaline) and norepinephrine.Phenoxybenzamine forms a permanent covalent bond with adrenergic receptors.
[16] [18] [22] By comparison, labetalol is a weaker β-adrenergic receptor blocker than propranolol, and has a weaker affinity for α-adrenergic receptors compared to phentolamine. [19] [18] Labetalol's dual α- and β-adrenergic antagonism has different physiological effects in short- and long-term situations.
Benign prostatic hyperplasia (BPH) is an enlarged prostate gland.Alpha-1 blockers are the most commonly used medicine to treat BPH. [6] Alpha-1 blockers are first line treatment for the symptoms of BPH in men.
Pindolol, sold under the brand name Visken among others, is a nonselective beta blocker which is used in the treatment of hypertension. [1] [2] It is also an antagonist of the serotonin 5-HT 1A receptor, preferentially blocking inhibitory 5-HT 1A autoreceptors, and has been researched as an add-on therapy to various antidepressants, such as clomipramine and the selective serotonin reuptake ...
Phentolamine, a reversible nonselective Alpha-adrenergic antagonist; Piberaline, a psychoactive drug This page was last edited on 1 June 2021, at 11:03 (UTC). ...