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Osteosclerosis is a disorder characterized by abnormal hardening of bone and an elevation in bone density. It may predominantly affect the medullary portion and/or cortex of bone.
Even sclerotic bone metastases are generally less radiodense than enostoses, and it has been suggested that bone metastasis should be the favored diagnosis between the two for bone lesions lower than a cutoff of 1060 Hounsfield units (HU). [11] If a biopsy is indicated, a CT scan is often used to localize the lesion before biopsy. [15]
Bone lesions can be sclerotic, lytic with sclerotic rims, or a mixture of the two with a soup-bubble look. About half of the patients have a single bone lesion, whereas the other half have several lesions. The most prevalent locations for bone lesions are the pelvis, spine, ribs, and proximal extremities. [5]
Nodular sclerosing Hodgkin lymphoma ("NSHL") or Nodular sclerosis is a form of Hodgkin's lymphoma [1] that is the most common subtype of HL in developed countries. It affects females slightly more than males and has a median age of onset at ~28 years.
Osteolytic lesion at the bottom of the radius, diagnosed by a darker section that indicates a loss of bone density. An osteolytic lesion (from the Greek words for "bone" (ὀστέον), and "to unbind" (λύειν)) is a softened section of a patient's bone formed as a symptom of specific diseases, including breast cancer and multiple myeloma.
Lesions may also be sclerotic, which is seen as radiodense. [76] Overall, the radiodensity of myeloma is between −30 and 120 Hounsfield units (HU). [ 77 ] Magnetic resonance imaging is more sensitive than simple X-rays in the detection of lytic lesions, and may supersede a skeletal survey, especially when vertebral disease is suspected.
Sclerosis (from Ancient Greek σκληρός (sklērós) 'hard') is the stiffening of a tissue or anatomical feature, usually caused by a replacement of the normal organ-specific tissue with connective tissue. The structure may be said to have undergone sclerotic changes or display sclerotic lesions, which refers to the process of sclerosis.
Radiographs in osteoid osteoma typically show a round lucency, containing a dense sclerotic central nidus (the characteristic lesion in this kind of tumor) surrounded by sclerotic bone. The nidus is seldom larger than 1.5 cm. [citation needed] The lesion can in most cases be detected on CT scan, bone scans and angiograms.
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