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The free radical theory of aging states that organisms age because cells accumulate free radical damage over time. [1] A free radical is any atom or molecule that has a single unpaired electron in an outer shell. [2] While a few free radicals such as melanin are not chemically reactive, most biologically relevant free radicals are highly ...
Oxidative stress mechanisms in tissue injury. Free radical toxicity induced by xenobiotics and the subsequent detoxification by cellular enzymes (termination).. Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. [1]
A free-radical reaction is any chemical reaction involving free radicals. This reaction type is abundant in organic reactions . Two pioneering studies into free radical reactions have been the discovery of the triphenylmethyl radical by Moses Gomberg (1900) and the lead-mirror experiment [ 1 ] described by Friedrich Paneth in 1927.
Nitric oxide is secreted as free radicals in an immune response and is toxic to bacteria and intracellular parasites, including Leishmania [31] and malaria; [32] [33] [34] the mechanism for this includes DNA damage [35] [36] [37] and degradation of iron sulfur centers into iron ions and iron-nitrosyl compounds. [38]
Hydroxyl radicals can attack the deoxyribose DNA backbone and bases, potentially causing a plethora of lesions that can be cytotoxic or mutagenic. Cells have developed complex and efficient repair mechanisms to fix the lesions. In the case of free radical attack on DNA, base-excision repair is the repair mechanism used. Hydroxyl radical ...
Free Radical Research, formerly Free Radical Research Communications, is an academic journal that publishes research papers, hypotheses, and reviews on free radicals, redox signaling, antioxidants, and oxidative damage. It is published by Informa Healthcare.
Pages in category "Free radicals" The following 82 pages are in this category, out of 82 total. This list may not reflect recent changes. ...
As part of their adaptation from marine life, terrestrial plants began producing non-marine antioxidants such as ascorbic acid (), polyphenols, and tocopherols.The evolution of angiosperm plants between 50 and 200 million years ago resulted in the development of many antioxidant pigments – particularly during the Jurassic period – as chemical defences against reactive oxygen species that ...