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Megavitamin-B 6 syndrome, also known as hypervitaminosis B 6, vitamin B 6 toxicity, and vitamin B 6 excess, [a] is a medical condition characterized by adverse effects resulting from excessive intake of vitamin B 6.
Outline an appropriate evaluation for suspected vitamin B6 toxicity. Review a reasonable differential diagnosis for patients presenting with signs and symptoms of pyridoxine toxicity. Select the treatment and management options available to the healthcare team for vitamin B6 toxicity.
We present a case of a 73-year-old male with a three-year history of progressive peripheral neuropathy who was found to have a serum vitamin B6 level of 259.9 nmol/L (reference range: 20-125 nmol/L) but only reported taking a daily multivitamin containing 6 mg of vitamin B6.
Even though there is a diagnosis code for B6 toxicity (E67.2 – Megavitamin-B6 Syndrome), our members found very few doctors that believed that B6 toxicity existed. We found even fewer doctors that understood that B6 toxicity was possible with minimal supplementation.
Symptoms of Vitamin B6 Excess. Taking very high doses of vitamin B6 may damage the nerves (called neuropathy), causing pain and numbness in the feet and legs. People may be unable to tell where their arms and legs are (position sense) and to feel vibrations. Thus, walking becomes difficult.
We describe seven adults who had ataxia and severe sensory-nervous-system dysfunction after daily high-level pyridoxine (vitamin B6) consumption. Four were severely disabled; all improved after...
In fruit and vegetables, B 6 is present principally as pyridoxine and its phosphate and glucoside. In meat and fish, it is mainly present as PLP and PMP. Synthesis of B 6 by the gut flora can make a significant contribution to our B 6 intake 2 and may explain why dietary B 6 deficiency is rare.
B6 dependency syndromes are a group of metabolic disorders that respond to large doses of vitamin B6. Although rare, pyridoxine-dependent seizure (PDS) is a recognized cause of...
Abstract. Seven young adults developed ataxia and sensory nervous system dysfunction after daily ingestion of 2–6 grams of pyridoxine for 2 to 40 months. vitamin B 6, pyridoxine, ataxia, dorsal root ganglia, sensory nervous system dysfunction, megavitamins, neuropathy. Topic: ataxia. ganglia, spinal. pyridoxine. vitamin b6. neuropathy. toxic effect
Vitamin B6 is frequently found in high doses, either directly as a pure vitamin or as a component in supplements and in fortified foods. Pyridoxine, a major form of vitamin B6, when in excess, is well known to cause an axonal polyneuropathy.