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4. Decongestant nasal sprays. Decongestant nasal sprays shrink blood vessels in the nasal passages. This helps relieve swelling. Popular decongestant nasal sprays include Afrin (oxymetazoline) and Neo-Synephrine (phenylephrine). Decongestant nasal sprays work fast, but they should only be used for about 3 to 5 days.