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Viral vector manufacturing methods often vary by vector, although most utilize an adherent or suspension-based system with mammalian cells. [72] For viral vector production on a smaller, laboratory setting, static cell culture systems like Petri dishes are typically used.
A viral vector vaccine is a vaccine that uses a viral vector to deliver ... The vaccinia virus's large size allows for a high potential for foreign gene insertion. [7]
How vectors work to transfer genetic material. Gene therapy utilizes the delivery of DNA into cells, which can be accomplished by several methods, summarized below. The two major classes of methods are those that use recombinant viruses (sometimes called biological nanoparticles or viral vectors) and those that use naked DNA or DNA complexes (non-viral methods).
This requires foreign DNA to be synthesized as part of a vector, which is designed to enter the desired host cell and deliver the transgene to that cell's genome. [4] Vectors utilized as the method for gene delivery can be divided into two categories, recombinant viruses and synthetic vectors (viral and non-viral). [2] [5]
Lentiviral vectors in gene therapy is a method by which genes can be inserted, modified, or deleted in organisms using lentiviruses.. Lentiviruses are a family of viruses that are responsible for diseases like AIDS, which infect by inserting DNA into their host cells' genome. [1]
Insertion of a vector into the target cell is usually called transformation for bacterial cells, [4] transfection for eukaryotic cells, [5] although insertion of a viral vector is often called transduction.
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