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While metamizole is a relatively safe medication, [24] it is not entirely devoid of adverse effects. [24] Metamizole has a potential of blood-related toxicity (blood dyscrasias), but causes less kidney, cardiovascular, and gastrointestinal toxicity than non-steroidal anti-inflammatory drugs (NSAIDs). [11]
Ingestion may also lead to nausea, mental disturbances, methemoglobinemia, chocolate-colored blood, dizziness, epigastric pain, difficulty in hearing, thready pulse and liver damage. Other symptoms reported via ingestion include hemolytic anemia, porphyria and severe gastrointestinal bleeding. Bone marrow depression also occurs.
Dipyridamole (trademarked as Persantine and others) is an antiplatelet drug of the nucleoside transport inhibitor and PDE3 inhibitor class that inhibits blood clot formation when given chronically and causes blood vessel dilation when given at high doses over a short time.
High blood pressure (Learn more about How to Lower Blood Pressure.) High cholesterol. Heart disease. Diabetes. Obesity. Sickle cell disease. Not exercising regularly. A sedentary lifestyle ...
Lighter Side. Medicare. News. Science & Tech. Shopping. Sports. Weather. 24/7 Help. ... "Your blood pressure is supposed to be under 140 over 90, optimally closer to 120 over 80."
For most people, recommendations are to reduce blood pressure to less than or equal to somewhere between 140/90 mmHg and 160/100 mmHg. [2] In general, for people with elevated blood pressure, attempting to achieve lower levels of blood pressure than the recommended 140/90 mmHg will create more harm than benefits, [3] in particular for older people. [4]
These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development.
Of these dipyrone is perhaps the most widely used. [3] [5] The basic structure has been also used in a number of newer drugs of other effects. [5] Edaravone is useful for prevention and/or therapy of arterial wall injury. [6] Eltrombopag is used to address low blood platelet count.