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SMCC is often used in bioconjugation to link proteins with other functional entities (fluorescent dyes, tracers, nanoparticles, cytotoxic agents). [1] For example, a targeted anticancer agent – trastuzumab emtansine ( antibody-drug conjugate containing an antibody trastuzumab chemically linked to a highly potent drug DM-1 ) – is prepared ...
9Å cryoEM reconstruction of Keyhole limpet hemocyanin (KLH). EMDB entry 1]. Keyhole limpet hemocyanin (KLH) is a large, multisubunit, oxygen-carrying, metalloprotein that is found in the hemolymph of the giant keyhole limpet, Megathura crenulata, a species of keyhole limpet that lives off the coast of California, from Monterey Bay to Isla Asuncion off Baja California.
SMCC or its water-soluble analog, Sulfo-SMCC, is commonly used to prepare antibody-hapten conjugates for antibody development. An in-vitro cross-linking method is PICUP ( photo-induced cross-linking of unmodified proteins ). [ 19 ]
The sulfonate ion. In organosulfur chemistry, a sulfonate is a salt, anion or ester of a sulfonic acid.Its formula is R−S(=O) 2 −O −, containing the functional group −S(=O) 2 −O −, where R is typically an organyl group, amino group or a halogen atom.
Crosslinkers are chemical reagents that play a crucial role in the preparation of conjugates used in biological research particularly immuno-technologies and protein studies.
SMCC may refer to: Organisations. Saint Mary's College of California; Santa Monica College; Science Media Centre of Canada; Sierra Madre Congregational Church;
N-sulfoglucosamine sulfohydrolase mechanism for the removal of sulfate from heparin or heparan sulfate substrate. [2]One of the proposed mechanisms for the N-sulfoglucosamine sulfohydrolase, depicted in the figure above, was inspired by a mechanism determined for a sulfatase enzymes, which similarly cleave sulfate ester groups from their substrates. [4]
Sulfonyl groups can be written as having the general formula R−S(=O) 2 −R′, where there are two double bonds between the sulfur and oxygen. [1]: 53 [2]Sulfonyl groups can be reduced to the sulfide with diisobutylaluminium hydride (DIBALH).