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The combination of increased pain signaling, and degeneration of pain-transmitting fibers, leads to a variable condition with signs and symptoms that can both vary and change over time. SCN9A gene mutations have been found in approximately 30 percent of individuals with small fiber neuropathy; SCN10A gene mutations are responsible for about 5 ...
The arthritis symptoms of Löfgren syndrome occur most frequently in the ankles, followed by the knees, wrists, elbows, and metacarpophalangeal joints. [72] Usually, true arthritis is not present, but instead, periarthritis appears as a swelling in the soft tissue around the joints that can be seen by ultrasonographic methods. [72]
Scleroderma is a group of autoimmune diseases that may result in changes to the skin, blood vessels, muscles, and internal organs. [2] [6] [8] The disease can be either localized to the skin or involve other organs, as well. [2]
The study, which involved 106 peri- and postmenopausal women and was presented at the Endocrine Society’s annual meeting in May, indicates women should self-monitor their vasomotor symptoms and ...
Usually, PMR only affects adults over the age of 50. [2] [21] The average age of a person who has PMR is about 70 years old, [13] [27] with the highest prevalence in those older than 70. [2] Women are three times as likely to get PMR as men. [2] People of Western and Northern European descent are more likely to get this disease. [13]
Cases involving the ascending aorta can present with the signs and symptoms of acute aortic dissection (e.g. severe pain, heart failure, cardiac arrest, fainting, stroke, ischemic peripheral neuropathy, and/or paraplegia), while cases involving large veins may present with acute swelling, pain, and tissue/organ dysfunctions in the areas drained ...
Frailty is not one specific disease, however is a combination of many factors. Frailty does not have a specific universal criteria on which it is diagnosed; there are a combination of signs and symptoms that can lead to a diagnosis of frailty. Evaluations can be done on physical status, weight fluctuations, or subjective symptoms. [14]
Common early symptoms include frequent tripping and falling and difficulty going up stairs. Foot drop in one or both feet can occur. [14] Part of the cause for this dysfunction is the early involvement of the quadriceps muscles. [1] Weakness of the tibialis anterior muscle is responsible for foot drop. Another common early symptom is trouble ...