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For all people over the age of 1, including women who are pregnant or lactating, they set an adequate intake of 15 μg/day (600 IU). [58] On the other hand the EU Commission defined nutrition labelling for foodstuffs as regards recommended daily allowances (RDA) for vitamin D to 5 µg/day (200 IU) as 100%. [174]
[9] [10] Vitamin-D supplements may not be effective in people with severe kidney disease. [11] [10] Excessive doses in humans can result in vomiting, constipation, muscle weakness, and confusion. [5] Other risks include kidney stones. [11] Doses greater than 40 000 IU (1000 μg) per day are generally required before high blood calcium occurs. [12]
In 2002, a Nature Made product [clarification needed] became the first dietary supplement verified by United States Pharmacopeia (USP). [2] [7] In 2016, Nature Made became the first company to prepare a USP-verified gummy brand. [clarification needed] [2] [8] [9] As of August 2023, Nature Made was manufacturing over 150 different types of ...
Ergocalciferol is available as a generic medication and over the counter. [6] In 2022, it was the 38th most commonly prescribed medication in the United States, with more than 15 million prescriptions. [10] [11] Certain foods such as breakfast cereal and margarine have ergocalciferol added to them in some countries.
Mapping of several bone diseases onto levels of vitamin D (calcidiol) in the blood [6] Normal bone vs. osteoporosis. Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body.
Long-term use of beta-carotene, vitamin A, and vitamin E supplements may shorten life, [2] and increase the risk of lung cancer in people who smoke (especially those smoking more than 20 cigarettes per day), former smokers, people exposed to asbestos, and those who use alcohol. [21]
Calcitriol is a hormone and the active form of vitamin D, normally made in the kidney. [8] [9] [10] It is also known as 1,25-dihydroxycholecalciferol.It binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes. [11]
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