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In the Dominican Republic, güevedoces (from Spanish: güevedoce, from Dominican Spanish güevos a los doce "testicles [1] at twelve") are children born with 5α-Reductase 2 deficiency. Güevedoces are raised as girls when they are born but, around age 12, when they commence puberty, their male genitalia starts to masculinize at puberty .
In mice, prenatal testosterone transfer causes higher blood concentrations of testosterone in 2M females when compared to 1M or 0M females. [6] This has a variety of consequences on later female behavior, physiology, and morphology. Below is a table comparing physiological, morphological, and behavioral differences of 0M and 2M female mice. [1]
Variants of the androgen receptor (AR) gene have also been discussed, in that non-right-handedness in men has been linked with greater CAG repeats in the AR gene, which in turn is associated with lower testosterone. A theory that high prenatal testosterone leads to neuronal and axonal loss in the corpus callosum is supported by this hypothesis ...
“Testosterone doesn’t drop off like estrogen does—it goes down a linear decline,” says Casperson. “Women in their mid-40s and 50s have half the testosterone that we had in our 20s.”
Hone Health reports on the factors responsible for testosterone levels in men and how they are affected by age and lifestyle.
So-called normal levels of testosterone are approximations, but can help researchers investigate disease and treatments. Testosterone: why defining a 'normal' level is hard to do Skip to main content
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Testosterone is the primary male sex hormone and androgen in males. [3] In humans, testosterone plays a key role in the development of male reproductive tissues such as testicles and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair.