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Osseointegration is also defined as: "the formation of a direct interface between an implant and bone, without intervening soft tissue". [1]An osseointegrated implant is a type of implant defined as "an endosteal implant containing pores into which osteoblasts and supporting connective tissue can migrate". [2]
Bone is a highly vascular tissue, and active formation of blood vessel cells, also from mesenchymal stem cells, is essential to support the metabolic activity of bone. The balance of bone formation and bone resorption tends to be negative with age, particularly in post-menopausal women, [ 7 ] often leading to a loss of bone serious enough to ...
The canal of the nutrient foramen is directed away from more active end of bone when one end grows more than the other. When bone grows at same rate at both ends, the nutrient artery is perpendicular to the bone. Most other bones (e.g. vertebrae) also have primary ossification centers, and bone is laid down in a similar manner. Secondary centers
[8] [9] It is the mineralization that gives bones rigidity. Bone is actively constructed and remodeled throughout life by specialized bone cells known as osteoblasts and osteoclasts. Within any single bone, the tissue is woven into two main patterns: cortical and cancellous bone, each with a distinct appearance and characteristics.
[8] [9] [10] At a site of active bone resorption, the osteoclast forms a specialized cell membrane, the "ruffled border", that opposes the surface of the bone tissue. This extensively folded or ruffled border facilitates bone removal by dramatically increasing the cell surface for secretion and uptake of the resorption compartment contents and ...
Bone resorption is resorption of bone tissue, that is, the process by which osteoclasts break down the tissue in bones [1] and release the minerals, resulting in a transfer of calcium from bone tissue to the blood. [2] The osteoclasts are multi-nucleated cells that contain numerous mitochondria and lysosomes. These are the cells responsible for ...
Osteons are components or principal structures of compact bone. During the formation of bone spicules, cytoplasmic processes from osteoblasts interconnect. This becomes the canaliculi of osteons. Since bone spicules tend to form around blood vessels, the perivascular space is greatly reduced as the bone continues to grow. When replacement to ...
Age, bone type, drug therapy and pre-existing bone pathology are factors that affect healing. The role of bone healing is to produce new bone without a scar as seen in other tissues which would be a structural weakness or deformity. [2] The process of the entire regeneration of the bone can depend on the angle of dislocation or fracture.