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Chikungunya is an infection caused by the Alphavirus chikungunya (CHIKV). [7] [8] [5] The disease was first identified in 1952 in Tanzania and named based on the Kimakonde words for "to become contorted". [5] Symptoms include fever and joint pain. [4] These typically occur two to twelve days after exposure. [5]
An analysis of the chikungunya virus's genetic code suggests that the increased severity of the 2005–present outbreak may be due to a change in the genetic sequence, altering the virus' viral coat protein, which potentially allows it to multiply more easily in mosquito cells. [3]
Even so, cases were reported in 14 states of the country. Mosquito-borne Zika virus is suspected to be the cause of 2,400 possible cases of microcephaly and 29 infant deaths in Brazil in 2015 (of the 2400 or so notified cases in 2015, 2165 were under investigation in December 2015, 134 were confirmed and 102 were ruled out for microcephaly). [114]
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Mosquito-borne flaviviruses also encode viral antagonists to the innate immune system in order to cause persistent infection in mosquitoes and a broad spectrum of diseases in humans. [25] The data on transmissibility via insect vectors of hepatitis C virus, also belonging to family Flaviviridae (as well as for hepatitis B virus, belonging to ...
Zika virus replicates in the mosquito's midgut epithelial cells and then its salivary gland cells. After 5–10 days, the virus can be found in the mosquito's saliva. If the mosquito's saliva is inoculated into human skin, the virus can infect epidermal keratinocytes, skin fibroblasts in the skin and the Langerhans cells.
If you think Zika sounds bad, just imagine contracting that virus and another exotic ailment from the same irritating little mosquito. You could get both Zika and chikungunya from one stupid ...
Chikungunya is characterized by a sudden high fever and intense joint pain, between four and seven days after infection. [4] [7] It can also cause headaches, muscle pain, fatigue, and rashes. [8] Most infected patients recover within 10 days, and deaths are rare. However, in some cases joint pain can linger for months or years.