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Allopurinol may also increase the activity or half-life of the following drugs, in order of seriousness and certainty of the interaction: [13] Ciclosporin Coumarin anticoagulants, such as warfarin (reported rarely, but is serious when it occurs)
The mean half-life of oxypurinol in patients with normal kidney function is 23 hours, although 95% of patients have half-lives between 9 and 38 hours. [7] The half-life of oxypurinol increases with decreasing kidney function, allowing it to build up over an extended period of time and reach higher steady-state concentrations; among those ...
Elimination half-life: 26.6-31.2 hours ... as a long-term prophylaxis when used with allopurinol to reduce the risk of ... other half contains double the ...
Half-life (symbol t ½) is the time required for a quantity (of substance) to reduce to half of its initial value.The term is commonly used in nuclear physics to describe how quickly unstable atoms undergo radioactive decay or how long stable atoms survive.
Absorption half-life 1 h, elimination half-life 12 h. Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma.
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An equianalgesic chart can be a useful tool, but the user must take care to correct for all relevant variables such as route of administration, cross tolerance, half-life and the bioavailability of a drug. [5] For example, the narcotic levorphanol is 4–8 times stronger than morphine, but also has a much longer half-life. Simply switching the ...
Febuxostat is used to treat chronic gout and hyperuricemia. [12] Febuxostat is typically recommended only for people who cannot tolerate allopurinol. [13] National Institute for Health and Clinical Excellence concluded that febuxostat is more effective than standard doses of allopurinol, but not more effective than higher doses of allopurinol.