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  2. Bone marrow failure - Wikipedia

    en.wikipedia.org/wiki/Bone_marrow_failure

    Inherited bone marrow failure syndromes represent a kind of premature aging of the bone marrow. In patients with these syndromes, as in elderly patients, mutations associated with clonal hematopoiesis may arise as an adaptive response to a progressively deteriorating hematopoietic niche, i.e., a depleting pool of Hematopoietic stem cells .

  3. Bone marrow - Wikipedia

    en.wikipedia.org/wiki/Bone_marrow

    With bone marrow stem cell transplants, chemotherapy patients have been able to increase their fertility as follicle damage is repaired. [43] As follicles are necessary for ovum attachment to the endometrium , it is important for these areas to be repaired in order to increase fertility.

  4. Hematopoietic stem cell - Wikipedia

    en.wikipedia.org/wiki/Hematopoietic_stem_cell

    Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood. [16] [17] [13] It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an identical twin).

  5. Hematopoietic stem cell transplantation - Wikipedia

    en.wikipedia.org/wiki/Hematopoietic_stem_cell...

    Stem-cell transplantation was pioneered using bone marrow-derived stem cells by a team at the Fred Hutchinson Cancer Research Center from the 1950s through the 1970s led by E. Donnall Thomas, whose work was later recognized with a Nobel Prize in Physiology or Medicine. Thomas' work showed that bone-marrow cells infused intravenously could ...

  6. Stem-cell therapy - Wikipedia

    en.wikipedia.org/wiki/Stem-cell_therapy

    Stem-cell therapy uses stem cells to treat or prevent a disease or condition. [1] As of 2024, the only FDA-approved therapy using stem cells is hematopoietic stem cell transplantation. [2] [3] This usually takes the form of a bone marrow or peripheral blood stem cell transplantation, but the cells can also be derived from umbilical cord blood.

  7. NHS to offer 'groundbreaking' sickle cell gene therapy - AOL

    www.aol.com/news/nhs-offer-groundbreaking-sickle...

    It is a multi-step process. First, blood stem cells from a patient's bone marrow (where all blood cells originate) are removed from the body. In the laboratory, a gene-editing tool called Crispr ...

  8. Stem cell - Wikipedia

    en.wikipedia.org/wiki/Stem_cell

    Bone marrow transplant is a form of stem cell therapy that has been used for many years because it has proven to be effective in clinical trials. [94] [95] Stem cell implantation may help in strengthening the left-ventricle of the heart, as well as retaining the heart tissue to patients who have suffered from heart attacks in the past. [96]

  9. Stem cell transplantation for articular cartilage repair

    en.wikipedia.org/wiki/Stem_cell_transplantation...

    Mesenchymal stem cells were originally discovered and studied as fibroblast-colony-forming cells in guinea-pig bone marrow and spleen cells by Friedenstein in the 1970s. [8] This study proved that the colony-forming units of bone marrow-derived stem cells were able to form cartilage once they were transplanted into a diffusion chamber. [9]

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