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  2. Contact activation system - Wikipedia

    en.wikipedia.org/wiki/Contact_activation_system

    The two arms of the contact system. PKa's cleavage of HK liberates BK and promotes inflammation. FXIIa's cleavage of FXI initiates coagulation. In the contact activation system or CAS, three proteins in the blood, factor XII (FXII), prekallikrein (PK) and high molecular weight kininogen (HK), bind to a surface and cause blood coagulation and ...

  3. Discovery and development of direct thrombin inhibitors

    en.wikipedia.org/wiki/Discovery_and_development...

    Coagulation cascade. When a blood vessel ruptures or gets injured, factor VII comes into contact with tissue factors which starts a process called the blood coagulation cascade. Its purpose is to stop bleeding and repair tissue damage. When this process is too active due to various problems the risk of blood clots or embolisms increases.

  4. Extrinsic pathway - Wikipedia

    en.wikipedia.org/wiki/Extrinsic_pathway

    Download as PDF; Printable version ... The extrinsic pathway of blood coagulation is also known as the tissue factor pathway and refers to a cascade of enzymatic ...

  5. Coagulation - Wikipedia

    en.wikipedia.org/wiki/Coagulation

    Coagulation cascade: It is a series of enzymatic reactions that lead to the formation of a stable blood clot. The endothelial cells release substances like tissue factor, which triggers the extrinsic pathway of the coagulation cascade. This is called as "secondary hemostasis". [20]

  6. Prothrombin activator - Wikipedia

    en.wikipedia.org/wiki/Prothrombin_activator

    Prothrombin activator is a complex of a dozen blood coagulation factors that functions in catalyzing prothrombin into thrombin. Prothrombin activator is released in the body by a cascade of chemical reactions in response to damage in a blood vessel.

  7. Robert Gwyn Macfarlane - Wikipedia

    en.wikipedia.org/wiki/Robert_Gwyn_Macfarlane

    Perhaps his greatest contribution to modern medicine was his deciphering of the Enzyme cascade process of blood coagulation. Working in 1951 with Prof Alexander Stuart Douglas at the Blood Coagulation Research Unit in Oxford they jointly discovered a second strain of haemophilia, now known as Haemophilia B , but then known as Christmas disease ...

  8. Ecarin - Wikipedia

    en.wikipedia.org/wiki/Ecarin

    Ecarin is a purified protein that is obtained from the venom of Echis carinatus. Ecarin is known to activate prothrombin, another protein that is a critical component of the blood clotting cascade. Therefore, measuring the activity of Ecarina is essential in understanding how it participates in the regulation of blood clotting. [5]

  9. Biochemical cascade - Wikipedia

    en.wikipedia.org/wiki/Biochemical_cascade

    An example would be the coagulation cascade of secondary hemostasis which leads to fibrin formation, and thus, the initiation of blood coagulation. Another example, sonic hedgehog signaling pathway, is one of the key regulators of embryonic development and is present in all bilaterians. [2]