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Onset of absorption after oral ingestion is delayed because cocaine is a weak base with a pKa of 8.6, and is thus in an ionized form that is poorly absorbed from the acidic stomach and easily absorbed from the alkaline duodenum. [11]
However, since blood is buffered with carbonate at physiological pH (near 7.4), free-base amines will be rapidly converted back into their acid form. In fact, 94.19% of cocaine will exist as the acid form under equilibrium at pH=7.4, calculated using the Henderson–Hasselbalch equation assuming a pKa of 8.61. [1]
It is a primary metabolite of cocaine, [1] and is pharmacologically inactive. [2] It is the corresponding carboxylic acid of cocaine, its methyl ester. It is formed in the liver by the metabolism of cocaine by hydrolysis, catalysed by carboxylesterases, and subsequently excreted in the urine. It is readily synthesised by boiling cocaine ...
This page provides supplementary chemical data on Cocaine in free base form. More commonly available "powder cocaine" is a hydrochloride salt whose properties will differ. Material Safety Data Sheet
Crack cocaine, commonly known simply as crack, and also known as rock, is a free base form of the stimulant cocaine that can be smoked. Crack offers a short, intense high to smokers. The Manual of Adolescent Substance Abuse Treatment calls it the most addictive form of cocaine.
How does pink cocaine affect someone? It can be hard to determine how the drug cocktail may affect someone after ingesting it. WebMD said this is due to several factors: the types of drugs mixed ...
"Pink cocaine" is a catchall term for a mixture of drugs that may or may not contain cocaine. It usually is made with ketamine — but as Dr. Adam Berman, a toxicologist and an addiction medicine ...
Oxi (abbr. from Portuguese oxidado) is a stimulant drug based on cocaine paste originally developed in the Brazilian Amazon forest region. [14] It is reportedly a mixture of cocaine paste, gasoline, kerosene and quicklime (calcium oxide). [15] This description may be a garbled account of an acid-base extraction procedure.