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Huntington's disease (HD), also known as Huntington's chorea, is an incurable neurodegenerative disease [7] that is mostly inherited. [8] The earliest symptoms are often subtle problems with mood or mental/psychiatric abilities. [9] [1] A general lack of coordination and an unsteady gait often follow. [2]
Huntington's disease is a neurodegenerative disease caused by mutations in a single gene HTT, that encodes for huntingtin protein. Symptoms include cognitive impairment and this usually declines further into dementia. [86] The first main symptoms of Huntington's disease often include: difficulty concentrating; memory lapses
The main causes are neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease because they affect or deteriorate brain functions. [7] Other diseases and conditions that cause NCDs include vascular dementia , frontotemporal degeneration , Lewy body disease , prion disease , normal pressure ...
Huntington's disease, which affects about 30,000 Americans, is a fatal, inherited disorder that causes progressive movement, psychological and cognitive problems. If a parent has it, their ...
The dementia [2] is more severe in patients with early onset of Huntington's disease. Parkinson's disease is characterised by features of dementia in older age. [ 3 ] [ 4 ] The adult type " leukodystrophy " also causes subcortical dementia with prominent frontal lobe features.
Parkinson's disease and Huntington's disease are both late-onset and associated with the accumulation of intracellular toxic proteins. Diseases caused by the aggregation of proteins are known as proteopathies, and they are primarily caused by aggregates in the following structures: [9] cytosol, e.g. Parkinson's and Huntington's
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