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A biogenic amine is a biogenic substance with one or more amine groups. They are basic nitrogenous compounds formed mainly by decarboxylation of amino acids or by amination and transamination of aldehydes and ketones. Biogenic amines are organic bases with low molecular weight and are synthesized by microbial, vegetable and animal metabolisms ...
The enzyme histidine decarboxylase (EC 4.1.1.22, HDC) is transcribed on chromosome 15, region q21.1-21.2, and catalyzes the decarboxylation of histidine to form histamine.In mammals, histamine is an important biogenic amine with regulatory roles in neurotransmission, gastric acid secretion and immune response.
Biogenic amine receptor are a variety of neurotransmitter receptors that are sensitive to biogenic amine neurotransmitters. They mostly belong to the G protein-coupled receptor (GPCR) family of transmembrane receptors , specifically within GPCR "Family A" ( Rhodopsin -like receptors). [ 1 ]
A phylogenetic tree showing how a number of monoamine receptors are related to each other. Monoamine neurotransmitter systems occur in virtually all vertebrates, where the evolvability of these systems has served to promote the adaptability of vertebrate species to different environments.
Trace amines are an endogenous group of trace amine-associated receptor 1 (TAAR1) agonists [1] – and hence, monoaminergic neuromodulators [2] [3] [4] – that are structurally and metabolically related to classical monoamine neurotransmitters. [5] Compared to the classical monoamines, they are present in trace concentrations. [5]
6571 214084 Ensembl ENSG00000165646 ENSMUSG00000025094 UniProt Q05940 Q8BRU6 RefSeq (mRNA) NM_003054 NM_172523 RefSeq (protein) NP_003045 NP_766111 Location (UCSC) Chr 10: 117.24 – 117.28 Mb Chr 19: 59.25 – 59.28 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Distribution of VMAT2 in the human brain. The solute carrier family 18 member 2 (SLC18A2) also known as vesicular ...
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