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IgG4-related disease (IgG4-RD), formerly known as IgG4-related systemic disease, is a chronic inflammatory condition characterized by tissue infiltration with lymphocytes and IgG4-secreting plasma cells, various degrees of fibrosis (scarring) and a usually prompt response to oral steroids.
IgG4-related ophthalmic disease (IgG4-ROD) is the recommended term to describe orbital (eye socket) manifestations of the systemic condition IgG4-related disease, [2] which is characterised by infiltration of lymphocytes and plasma cells and subsequent fibrosis in involved structures. It can involve one or more of the orbital structures.
The CMPA also provides compensation to patients and their families proven to have been harmed by negligent medical care (fault in Québec). [1] In 2016, the CMPA's membership list totaled 95,691 physicians. [2] The organization has its headquarters in Ottawa, Ontario, Canada.
Although a clear understanding of the various skin lesions in IgG4-related disease is a work in progress, skin lesions have been classified into subtypes based on documented cases: [2] Angiolymphoid hyperplasia with eosinophilia (or lesions that mimic it) [3] and cutaneous pseudolymphoma; Cutaneous plasmacytosis [Note 1]
Canada's Drug Agency (CDA; French: L’Agence des médicaments du Canada, AMC) is a pan-Canadian health organization responsible for coordinating and aligning drug ...
Michael Garron Hospital (MGH), formerly Toronto East General Hospital (TEGH), is a community teaching hospital located at 825 Coxwell Avenue in East York, Toronto, Ontario, Canada. Overview [ edit ]
IgG deficiency is a form of dysgammaglobulinemia where the proportional levels of the IgG isotype are reduced relative to other immunoglobulin isotypes.. IgG deficiency is often found in children as transient hypogammaglobulinemia of infancy, which may occur with or without additional decreases in IgA or IgM.
Therapeutic, diagnostic and preventive monoclonal antibodies are clones of a single parent cell. When used as drugs, the International Nonproprietary Names (INNs) end in -mab.