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Phytosterols further reduce cholesterol levels by about 9% to 17% in statin users. [28] The type or dose of statin does not appear to affect the cholesterol-lowering efficacy of phytosterols. [29] Because of their cholesterol reducing properties, some manufacturers are using sterols or stanols as a food additive. [3] [30]
Men with prostate cancer may be characterized as low, intermediate, or high risk for having/developing metastatic disease or dying of prostate cancer. PSA level is one of three variables on which the risk stratification is based; the others are the grade of prostate cancer ( Gleason grading system ) and the stage of cancer based on physical ...
Routine screening is not recommended for bladder cancer, [170] testicular cancer, [171] ovarian cancer, [172] pancreatic cancer, [173] or prostate cancer. [ 174 ] Recommends mammography for breast cancer screening every two years from ages 50–74, but does not recommend either breast self-examination or clinical breast examination . [ 175 ]
In men, disease states are associated with extremes in polyglutamine tract length; prostate cancer, [20] hepatocellular carcinoma, [21] and intellectual disability [13] are associated with too few repetitions, while spinal and bulbar muscular atrophy (SBMA) is associated with a CAG repetition length of 40 or more. [22]
Medical therapy with oral bile acids has been used to treat small cholesterol stones, and for larger cholesterol gallstones when surgery is either not possible or unwanted. CDCA treatment can cause diarrhea, mild reversible hepatic injury, and a small increase in the plasma cholesterol level. [59] UDCA may need to be taken for years. [54]
This is a transcription factor that is inactive when cholesterol levels are high, and active when cholesterol levels are low. When cholesterol levels fall, SREBP is released from the nuclear membrane or endoplasmic reticulum , it then migrates to the nucleus and causes the transcription of the HMG-CoA reductase gene .
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