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Aldehyde dehydrogenase is a polymorphic enzyme [3] responsible for the oxidation of aldehydes to carboxylic acids. [3] There are three different classes of these enzymes in mammals: class 1 (low K m, cytosolic), class 2 (low K m, mitochondrial), and class 3 (high K m, such as those expressed in tumors, stomach, and cornea). In all three classes ...
This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase that catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia , an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5 ...
Aldehyde dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the ALDH2 gene located on chromosome 12. [ 5 ] [ 6 ] ALDH2 belongs to the aldehyde dehydrogenase family of enzymes. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism.
The systematic name of this enzyme class is aldehyde:NAD(P)+ oxidoreductase. Other names in common use include aldehyde dehydrogenase [NAD(P)+] , and ALDH . This enzyme participates in 5 metabolic pathways : glycolysis / gluconeogenesis , histidine metabolism , tyrosine metabolism , phenylalanine metabolism , and metabolism of xenobiotics by ...
In enzymology, an aldehyde dehydrogenase (NADP+) (EC 1.2.1.4) is an enzyme that catalyzes the chemical reaction. an aldehyde + NADP + + H 2 O an acid + NADPH + H +. The 3 substrates of this enzyme are aldehyde, NADP +, and H 2 O, whereas its 3 products are acid, NADPH, and H +.
ALDH3A1's catalytic mechanism mirrors that of other enzymes of the aldehyde dehydrogenase family. The sulfur atom of Cys244 attacks the carbonyl of the aldehyde substrate in a nucleophilic attack that releases a hydride ion. The hydride ion is accepted by the NAD(P)+ bound to the Rossmann fold.
Aldehyde dehydrogenase isozymes are NAD(P)-dependent dehydrogenases that catalyze the oxidation of an aldehyde into the corresponding carboxylic acid while reducing NAD+ or NADP+. ALDH1A1 is the only ALDH1 isozyme known to oxidize 9-cis retinaldehyde into 9-cis retinoic acid [ 7 ] and thus serve as the only known activator of the rexinoid ...
The aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular gene spans about 20 kb of genomic DNA and is composed of 9 coding exons.