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The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD) . [ 1 ]
The polymorphic layer is often called the hilus or hilar region. [14] The neurons in the polymorphic layer, including mossy cells and GABAergic interneurons, primarily receive inputs from the granule cells in the dentate gyrus in the form of mossy fibers and project to the inner molecular layer of the dentate gyrus via the associational ...
Brain at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (view tree for regions of the brain) BrainMaps.org; BrainInfo (University of Washington) "Brain Anatomy and How the Brain Works". Johns Hopkins Medicine. 14 July 2021. "Brain Map". Queensland Health. 12 July 2022.
Human hippocampus Nissl-stained coronal section of the brain of a macaque monkey, showing hippocampus (circled). Hippocampus anatomy describes the physical aspects and properties of the hippocampus, a neural structure in the medial temporal lobe of the brain.
A recent study has also revealed atrophy as a result of depression, but this can be stopped with anti-depressants even if they are not effective in relieving other symptoms. [ 125 ] Chronic stress resulting in elevated levels of glucocorticoids , notably of cortisol , is seen to be a cause of neuronal atrophy in the hippocampus.
The dentate gyrus (DG) is part of the hippocampal formation in the temporal lobe of the brain, which also includes the hippocampus and the subiculum.The dentate gyrus is part of the hippocampal trisynaptic circuit and is thought to contribute to the formation of new episodic memories, [1] [2] the spontaneous exploration of novel environments [2] and other functions. [3]
This wave of activity, called a cortical spreading depression, follows a particular pattern across the brain and can create a few different patterns of light in your vision. For example, the Mayo ...
Causes: Family history, previous diagnosis of a mood disorder, trauma, stress or major life changes in the case of depression, physical illness or use of certain medications. Depression has been linked to major diseases such as cancer, diabetes, Parkinson's disease and heart disease, Brain structure and function in the case of bipolar disorder. [1]
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