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One manifestation of this is enzymes or receptors that have multiple binding sites where the affinity of the binding sites for a ligand is apparently increased, positive cooperativity, or decreased, negative cooperativity, upon the binding of a ligand to a binding site. For example, when an oxygen atom binds to one of hemoglobin's four binding ...
Cooperativity can be positive or negative, meaning that it becomes more or less likely that successive ligand molecules will bind to the receptor molecule. Cooperative binding is observed in many biopolymers, including proteins and nucleic acids. Cooperative binding has been shown to be the mechanism underlying a large range of biochemical and ...
The binding of a ligand to a macromolecule is often enhanced if there are already other ligands present on the same macromolecule (this is known as cooperative binding). The Hill equation is useful for determining the degree of cooperativity of the ligand(s) binding to the enzyme or receptor.
David Johnson, Deutsch's student in the study of social psychology, with his brother Roger Johnson, a science educator, and their sister, educator Edye Johnson Holubec, further developed positive interdependence theory as part of their research and work in teacher and professional training at the Cooperative Learning Center at the University of Minnesota (founded in 1969).
Researchers suggested that a combination of low self-directedness and low cooperativeness form a general factor common to all personality disorders. [4] The specific combination of low self-directedness, low cooperativeness, and high self-transcendence has been described as a "schizotypal personality" style by Cloninger and colleagues, [4] and has been found to be associated with high levels ...
The positive reciprocity norm is a common social expectation in which a person who helps another person can expect positive feedback whether in the form of a gift, a compliment, a loan, a job reference, etc. In social psychology, positive reciprocity refers to responding to a positive action with another positive action (rewarding kind actions).
Shared intentionality is a concept in psychology that describes the human capacity to engage with the psychological states of others. According to conventional wisdom in cognitive sciences, shared intentionality supports the development of everything from cooperative interactions and knowledge assimilation to moral identity and cultural evolution that provides building societies, being a pre ...
The sequential model (also known as the KNF model) is a theory that describes cooperativity of protein subunits. [1] It postulates that a protein's conformation changes with each binding of a ligand, thus sequentially changing its affinity for the ligand at neighboring binding sites.