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Delayed or suboptimal treatment often allows these kidney stones to act as a nidus for P. mirabilis growth causing recurrent infections despite antibiotic treatment. If the stones grow large enough they can cause obstruction and kidney failure. Proteus species can also cause wound infections, sepsis, and pneumonia, mostly in hospitalized ...
Nitrofurantoin, sold under the brand name Macrobid among others, is an antibacterial medication of the nitrofuran class used to treat urinary tract infections (UTIs), although it is not as effective for kidney infections. [16] It is taken by mouth. [16] Common side effects include nausea, loss of appetite, diarrhea, and headaches. [16]
[108] [107] Cephalexin or nitrofurantoin are typically used because they are generally considered safe in pregnancy. [107] A kidney infection during pregnancy may result in preterm birth or pre-eclampsia (a state of high blood pressure and kidney dysfunction during pregnancy that can lead to seizures). [42]
A kidney stone is a hard object, which can be as small as a grain of salt or as big as a golf ball, made from chemicals—calcium oxalate, uric acid, struvite, and cystine—found in our urine ...
Kidney stone disease, also known as renal calculus disease, nephrolithiasis or urolithiasis, is a crystallopathy where a solid piece of material (renal calculus) develops in the urinary tract. [2] Renal calculi typically form in the kidney and leave the body in the urine stream. [2] A small calculus may pass without causing symptoms. [2]
The use of nitrofurantoin is contraindicated in patients with an estimated GFR of less than 30 mL/min/1.73m 2 as drug accumulation can lead to increased side effects and impaired recovery of the urinary tract, increasing the risk of treatment failure. [29] The use of TMP/SMX also raises concerns in patients with kidney disease.
In kidney stones, calcium oxalate is the most common mineral type (see nephrolithiasis). Uric acid is the second most common mineral type, but an in vitro study showed uric acid stones and crystals can promote the formation of calcium oxalate stones. [1]
Hypomagnesemic hypercalciuric nephrocalcinosis (magnesium-losing kidney)[248250] PCLN1: 3q27: AR: Nephrocalcinosis, renal failure, ocular/hearing defects, polyruria, polydipsia, recurrent urinary tract infections, recurrent renal colic, normotensive: Plasma: ↓Mg, ↑PTH; Urine: ↑Ca, ↑Mg Distal Tubule/Collecting Duct: Liddle's syndrome ...
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