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  2. Uracil-DNA glycosylase - Wikipedia

    en.wikipedia.org/wiki/Uracil-DNA_glycosylase

    Uracil-DNA glycosylase (also known as UNG or UDG) is an enzyme. Its most important function is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosidic bond and initiating the base-excision repair (BER) pathway.

  3. DNA glycosylase - Wikipedia

    en.wikipedia.org/wiki/DNA_glycosylase

    This entry represents various uracil-DNA glycosylases and related DNA glycosylases , such as uracil-DNA glycosylase, [9] thermophilic uracil-DNA glycosylase, [10] G:T/U mismatch-specific DNA glycosylase (Mug), [11] and single-strand selective monofunctional uracil-DNA glycosylase (SMUG1). [12] Uracil DNA glycosylases remove uracil from DNA ...

  4. SMUG1 - Wikipedia

    en.wikipedia.org/wiki/SMUG1

    Single-strand selective monofunctional uracil DNA glycosylase is an enzyme that in humans is encoded by the SMUG1 gene. [ 4 ] [ 5 ] [ 6 ] SMUG1 is a glycosylase that removes uracil from single- and double-stranded DNA in nuclear chromatin, thus contributing to base excision repair .

  5. Base excision repair - Wikipedia

    en.wikipedia.org/wiki/Base_excision_repair

    Some glycosylase-lyases can further perform δ-elimination, which converts the 3' aldehyde to a 3' phosphate. A wide variety of glycosylases have evolved to recognize different damaged bases. Examples of DNA glycosylases include Ogg1, which recognizes 8-oxoguanine, MPG, which recognizes 3-methyladenine, and UNG, which removes uracil from DNA.

  6. Uracil - Wikipedia

    en.wikipedia.org/wiki/Uracil

    Therefore, if there were an organism that used uracil in its DNA, the deamination of cytosine (which undergoes base pairing with guanine) would lead to formation of uracil (which would base pair with adenine) during DNA synthesis. Uracil-DNA glycosylase excises uracil bases from double-stranded DNA. This enzyme would therefore recognize and cut ...

  7. AP site - Wikipedia

    en.wikipedia.org/wiki/AP_site

    A variety of glycosylases that recognize different types of damage exist, including oxidized or methylated bases, or uracil in DNA. The AP site can then be cleaved by an AP endonuclease, leaving 3'-hydroxyl and deoxyribose-5-phosphate termini (see DNA structure). In alternative fashion, bifunctional glycosylase-lyases can cleave the AP site ...

  8. Hyper-IgM syndrome type 5 - Wikipedia

    en.wikipedia.org/wiki/Hyper-IgM_syndrome_type_5

    These three patients instead had mutations in the catalytic domain of uracil-DNA glycosylase, an enzyme that removes uracil from DNA. In hyper-IgM syndromes , patients are deficient in the immunoglobulins , IgG , IgE and IgA types since the antibody producing B cells can not carry out the gene recombination steps necessary to class switch from ...

  9. Activation-induced cytidine deaminase - Wikipedia

    en.wikipedia.org/wiki/Activation-induced...

    The uracil may be excised by uracil-DNA glycosylase (UNG), resulting in an abasic site. This abasic site (or AP, apurinic/apyrimidinic) may be copied by a translesion synthesis DNA polymerase such as DNA polymerase eta, resulting in random incorporation of any of the four nucleotides, i.e. A, G, C, or T.