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Pernicious anemia is the most common cause of vitamin B 12 deficiency anemia in adults, which results from malabsorption of vitamin B 12 due to a lack or loss of intrinsic factor. [2] [8] There are relatively few studies which have assessed the impact of haematological measures in response to B 12 supplementation.
What causes b12 deficiency. Causes of B12 deficiency include: A lack of vitamin B12 in the diet. Gastrointestinal disorders that interfere with vitamin B12 absorption, like Crohn's or celiac disease.
Anemia is a deficiency in the size or number of red blood cells or in the amount of hemoglobin they contain. [1] This deficiency limits the exchange of O 2 and CO 2 between the blood and the tissue cells. [1] Globally, young children, women, and older adults are at the highest risk of developing anemia. [1]
Adults need about 2.4 micrograms of B12 a day (that much can be found in one portion of salmon, canned tuna or ground beef), with pregnant and nursing women needing slightly more (2.6 and 2.8 mcg ...
[2] [4] Plants do not need cobalamin and carry out the reactions with enzymes that are not dependent on it. [5] Vitamin B 12 is the most chemically complex of all vitamins, [6] and for humans the only vitamin that must be sourced from animal-derived foods or supplements. [2] [7] Only some archaea and bacteria can synthesize vitamin B 12. [8]
It most usually occurs in postmenopausal women. Vitamin B12 deficiency anemia: E53.8: 13905: Vitamin B12 deficiency anemia occurs when a "lower-than-normal" amount of the vitamin B12 is available within the body, leading to a decreased production of healthy red blood cells. [7] Vitamin B12 deficiency anemia due to intrinsic factor deficiency: D51.0
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Pernicious anemia is the most common cause of clinically evident vitamin B 12 deficiency worldwide. [14] Pernicious anemia due to autoimmune problems occurs in about one per 1000 people in the US. Among those over the age of 60, about 2% have the condition. [ 8 ]
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