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The duration of action of "non-drowsy" antihistamines is generally 24 hours with the peak effect occurring eight to twelve hours after taking the dose. While none of these second/third-generation antihistamines are considered head and shoulders better than another there are some differences to consider. Comparing Non-Drowsy Antihistamines
In may not be what we consider "typical allergy symptoms" such as watery eyes and a runny nose, but it would nonetheless still be considered an allergy. As such, it is important to try and discern the cause of the allergy and eliminate the allergen if possible. For your symptoms, looking towards an antihistamine medication is a good idea.
' Non-drowsy Benadryl' simply refers to an alternative antihistamine that is not diphenhydramine. Depending on what you are using the Benadryl for, you may be able to substitute other over-the-counter antihistamines. If you are looking for a non-drowsy allergy medication, "second-generation" antihistamines are your best bet.
Since most patient are looking for an allergy medicine that is completely non-drowsy, Claritin and Allegra top the list as the best over the counter allergy medicines. For a first time allergy medication user, Claritin is the most highly recommended due to the price, duration of action and absence of sedation as a side effect.
It is classified as non-drowsy and lasts around 24 hours per dose. It is most commonly used to prevent and treat perennial/seasonal allergies but can also be used intermittently for other things, like itching and hives. Claritin is safe to take with Alka-Seltzer Plus Cold & Flu Day. It does not interact with any of the drugs in that product.
Claritin and Allegra are classified and marketed as "non-drowsy". Zyrtec can cause drowsiness in a small percentage of people and is therefore not classified as non-drowsy. Specifically, studies show that Claritin (loratadine) and Allegra (fexofenadine) have the lowest rates of drowsiness, with it occurring in 2-4% of patients compared to 22% ...
Does Allegra (fexofenadine) make you drowsy? Answer. Allegra (fexofenadine), a second generation antihistamine, is considered non-drowsy and should not cause sedation in most individuals. Other second generation antihistamines include: Zyrtec (cetirizine) Claritin (loratadine) Xyzal (levocetirizine)
The only drawback of this medication is that is causes drowsiness in ~5-10% of people and therefore is NOT marketed or labeled as non-drowsy. Fexofenadine (Allegra) - The last of the formally prescription antihistamines to go over the counter. It has the fastest onset of action of the OTC allergy medications and is non-drowsy.
All of the second generation antihistamines last 24 hours per dose and are non-drowsy (with the exception of Zyrtec). While comparative studies generally show no significant difference in efficacy between the drugs, Xyzal does appear to be the most potent and effective medication for allergen induced reactions in the majority of individuals.
Second-generation antihistamines offer significant benefit over first generation antihistamines, such as Benadryl in that they last about 24 hours per dose and are typically non-drowsy. Unfortunately, Zyrtec (cetirizine) is the only second-generation antihistamine that is known to cause significant sedation in individuals.