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Samoyeds can be affected by basement membrane disease of the kidneys. It is inherited through the X chromosome and is therefore more severe in affected male dogs. Findings in male dogs include the presence of protein and glucose in the urine and the inability to concentrate urine, and progression to kidney failure by the age of 9 months and death by 16 months. [3]
The disease is specific to the Samoyed, in that the Samoyed is the only breed of dog to show the more rapid progression to kidney failure and death, as well as affecting males to a much more severe degree than females. The Samoyed, however, is not the only breed of dog to suffer from life-threatening renal diseases.
It can result in chronic kidney failure, hypoalbuminemia, which can cause ascites and peripheral edema, and nephrotic syndrome, which can cause hypertension or hypercoagulability. [156] Familial renal disease is an uncommon cause of kidney failure in young dogs. Most causes are breed-related (familial) and some are inherited.
By the end of March, veterinary organizations reported more than 100 pet deaths among nearly 500 cases of kidney failure. [1] However, many sources speculate that the actual number of affected pets may never be known, and experts think that the actual death toll could potentially reach into the thousands.
Acute tubular necrosis (ATN) is a medical condition involving the death of tubular epithelial cells that form the renal tubules of the kidneys.Because necrosis is often not present, the term acute tubular injury (ATI) is preferred by pathologists over the older name acute tubular necrosis (ATN). [1]
Preliminary research in kidney cell lines have identified nitazoxanide, closantel sodium, and closantel as drugs which have the most potential as broad-spectrum antiviral agents against canine parvovirus and its various subspecies, raising the prospect that these drugs may yield potential for future treatments of this disease.
Grapes and raisins can cause acute kidney failure in dogs [40] The exact mechanism is unknown, nor is there any means to determine the susceptibility of an individual dog. While as little as one raisin can be toxic to a susceptible 10 pounds (4.5 kg) dog, some other dogs have eaten as much as a pound of grapes or raisins at a time without ill ...
Despite its relative rarity compared to limb prosthesis, strides have been made over the decades, with notable milestones such as the first pacemaker surgery on a dog in 1968 and successful kidney transplants in cats since the mid-1980s. This field faces challenges, particularly in canine programs, due to issues related to immunosuppression.
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