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Feline hyperaldosteronism is a disease in cats. The symptoms are caused by abnormally high concentrations of the hormone aldosterone, [1] which is secreted by the adrenal gland. The high concentrations of aldosterone may be due directly to a disorder of the adrenal gland (primary hyperaldosteronism), or due to something outside of the adrenal ...
Cats are carnivores. The kidney is a vital organ with a variety of tasks. It plays an important role in maintaining the water, electrolyte and acid-base balance, in the excretion of toxic metabolic degradation products such as urea and in the recovery of valuable substances such as glucose, amino acids, peptides and minerals initially filtered out of the blood during ultrafiltration in the ...
Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. [4] [5] It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. [6]
Is your cat drinking more water than usual? It may not be a good thing. Vet. Dara Johns explains the signs of kidney failure and available treatment.
For people with hyperplasia of both glands, successful treatment is often achieved with spironolactone or eplerenone, drugs that block the aldosterone receptor. With its antiandrogen effect, spironolactone drug therapy may have a range of side effects in males and females, including gynecomastia and irregular menses. These symptoms occur less ...
The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate the mineralocorticoid receptor due to the non-selectivity of the receptor, leading to aldosterone-like effects in the kidney.
Feline disease refers to infections or illnesses that affect cats. They may cause symptoms, sickness or the death of the animal. Some diseases are symptomatic in one cat but asymptomatic in others. Feline diseases are often opportunistic and tend to be more serious in cats that already have concurrent sicknesses.
Cats can be affected by hyperaldosteronism. The most common signs in cats are muscle weakness and loss of eyesight, although only one of these signs may be present. [ 12 ] Muscle weakness is due to low potassium concentrations in the blood, and signs of muscle weakness, such as being unable to jump, may be intermittent. [ 12 ]