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Common adverse effects include diarrhea, nausea, and abdominal pain. [16] It has a small risk of causing low blood sugar. [16] High blood lactic acid level is a concern if the medication is used in overly large doses or prescribed in people with severe kidney problems. [23] [24] Metformin is a biguanide anti-hyperglycemic agent. [16]
Buffer capacity falls to 33% of the maximum value at pH = pK a ± 1, to 10% at pH = pK a ± 1.5 and to 1% at pH = pK a ± 2. For this reason the most useful range is approximately pK a ± 1. When choosing a buffer for use at a specific pH, it should have a pK a value as close as possible to that pH. [2]
The pH-dependence of the activity displayed by enzymes and the pH-dependence of protein stability, for example, are properties that are determined by the pK a values of amino acid side chains. The pK a values of an amino acid side chain in solution is typically inferred from the pK a values of model compounds (compounds that are similar to the ...
It has been used historically as an alternative to the McIlvaine buffer, which has a smaller pH range of effectiveness (from 2 to 8). [1] Universal buffers consist of mixtures of acids of diminishing strength (increasing pK a), so that the change in pH is approximately proportional to the amount of alkali added. It consists of a mixture of 0.04 ...
This procedure is illustrated in an ICE table which can also be used to calculate the pH when some additional (strong) acid or alkaline has been added to the system, that is, when C A ≠ C H. For example, what is the pH of a 0.01 M solution of benzoic acid, pK a = 4.19? Step 1: = =
Additionally, a change in pH could cause micelles to swap their inner and outer molecules depending on the properties of the polymers involved. [1] Diagram of a micelle, showing how in aqueous solution the hydrophilic parts of the molecules would be on the outside and the hydrophobic parts would be on the inside of the sphere.
pH = 1 / 2 pK w + 1 / 2 log (1 + T A / K a ) With a dilute solution of the weak acid, the term 1 + T A / K a is equal to T A / K a to a good approximation. If pK w = 14, pH = 7 + (pK a + log T A)/2. This equation explains the following facts: The pH at the end-point depends mainly on the strength of the ...
Tris-buffered saline (TBS) is a buffer used in some biochemical techniques to maintain the pH within a relatively narrow range. Tris (with HCl) has a slightly alkaline buffering capacity in the 7–9.2 range. The conjugate acid of Tris has a pK a of 8.07 at 25 °C. The pK a declines approximately 0.03 units per degree Celsius rise in ...