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Cataplexy is the first symptom to appear in about 10% of cases of narcolepsy, [2] caused by an autoimmune destruction of hypothalamic neurons that produce the neuropeptide hypocretin (also called orexin), which regulates arousal and has a role in stabilization of the transition between wake and sleep states. [3]
Narcolepsy is often mistaken for depression, epilepsy, the side effects of medications, poor sleeping habits or recreational drug use, making misdiagnosis likely. [citation needed] While narcolepsy symptoms are often confused with depression, there is a link between the two disorders. Research studies have mixed results on co-occurrence of ...
Sodium oxybate is approved by the U.S. Food and Drug Administration for the treatment of cataplexy associated with narcolepsy [21] and excessive daytime sleepiness (EDS) associated with narcolepsy. [22] GHB has been shown to reliably increase slow-wave sleep [23] [24] [25] and decrease the tendency for REM sleep in modified multiple sleep ...
Related: Benadryl for Dogs: Side Effects of Long-Term Use Signs of Benadryl Overdose in Dogs At normal doses, Benadryl is quite safe, but a survey of over 600 dogs (1) found the following signs of ...
Melatonin and clonazepam are the most frequently used, [2] and are comparably effective, [24] but melatonin offers a safer alternative, because clonazepam can produce undesirable side effects. [17] Medications that may worsen RBD and should be stopped if possible are tramadol, mirtazapine, antidepressants, and beta blockers. [2]
A large percentage of people with narcolepsy have cataplexy as well, which along with excessive sleepiness disrupts a person’s ability to socialize, work at a job, drive a car or even have close ...
Service dogs can do so many helpful things to make their owner's life more accessible and independent, but for some special needs dogs like Toast the Goldendoodle, a service human comes in handy!
Orexin (/ ɒ ˈ r ɛ k s ɪ n /), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. [5] It exists in the forms of orexin-A and orexin-B.The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells ...