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The first adverse reactions to aspirin were described in 1902 in Germany, only four years after aspirin's commercial introduction. [53] The first published report of an aspirin-induced asthma attack was in 1911. [54] Initial reports on the linkage between asthma, aspirin, and nasal polyposis were made by Georges-Fernand Widal et al. in 1922. [55]
Aspirin is non-selective and irreversibly inhibits both forms [4] (but is weakly more selective for COX-1 [5]). It does so by acetylating the hydroxyl of a serine residue at the 530 amino acid position. [6] Normally COX produces prostaglandins, most of which are pro-inflammatory, and thromboxanes, which promote clotting.
Aspirin or other over-the-counter analgesics are widely recognized as effective for the treatment of tension headaches. [96] Aspirin, especially as a component of an aspirin/paracetamol/caffeine combination, is considered a first-line therapy in the treatment of migraine, and comparable to lower doses of sumatriptan. It is most effective at ...
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Salicylate poisoning, also known as aspirin poisoning, is the acute or chronic poisoning with a salicylate such as aspirin. [1] The classic symptoms are ringing in the ears , nausea , abdominal pain , and a fast breathing rate . [ 1 ]
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"In reality," he said, "foodborne illnesses can lead to severe and long-lasting health issues, hospitalization or even death, especially for vulnerable populations like the immunocompromised ...
It is also known as expired air resuscitation (EAR), expired air ventilation (EAV), rescue breathing, or colloquially the kiss of life. It was introduced as a life-saving measure in 1950. [5] Mouth-to-mouth resuscitation is a part of most protocols for performing cardiopulmonary resuscitation (CPR) [6] [7] making it an essential skill for first ...