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Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage). [1] Sustained-release dosage forms are dosage ...
Self-microemulsifying drug delivery system; Sink condition; Smoking; Snuff (tobacco) Softgel; Sol–gel process; Solution (chemistry) Subcutaneous administration; Suppository; Suspension (chemistry) Modified-release dosage; Syrup
Depot injections can be created by modifying the drug molecule itself, as in the case of prodrugs, or by modifying the way it is administered, as in the case of oil/lipid suspensions. Depot injections can have a duration of action of one month or greater and are available for many types of drugs, including antipsychotics and hormones .
Release (Liberation) is the first step in the process by which medication enters the body and liberates the active ingredient that has been administered. The pharmaceutical drug must separate from the vehicle or the excipient that it was mixed with during manufacture. Some authors split the process of liberation into three steps: disintegration ...
Drug delivery is a concept heavily integrated with dosage form and route of administration, the latter sometimes being considered part of the definition. [9] While route of administration is often used interchangeably with drug delivery, the two are separate concepts.
Dosage forms vary depending on the method/route of administration, which can include many types of liquid, solid, and semisolid forms. Common dosage forms include pills, tablets, capsules, drinks, and syrups, among others. A combination drug (or fixed-dose combination; FDC) is a product that contains more than one active ingredient (e.g., one ...
A low drug load may cause homogeneity problems. A high drug load may pose flow problems or require large capsules if the compound has a low bulk density. By the time phase III clinical trials are reached, the formulation of the drug should have been developed to be close to the preparation that will ultimately be used in the market. A knowledge ...
Drug Master File (DMF) is a document containing complete information on an Active Pharmaceutical Ingredient (API) or finished drug dosage form.It is known as European Drug Master File (EDMF) or Active Substance Master File (ASMF) and US-Drug Master file (US-DMF) in Europe and United States respectively.