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Pernicious anemia is the most common cause of clinically evident vitamin B 12 deficiency worldwide. [14] Pernicious anemia due to autoimmune problems occurs in about one per 1000 people in the US. Among those over the age of 60, about 2% have the condition. [8] It more commonly affects people of northern European descent. [2]
The most common are pernicious anemia possibly leading to vitamin B 12 deficiency; and malabsorption of iron, leading to iron deficiency anaemia. [2] It can be caused by persistent infection with Helicobacter pylori, or can be autoimmune in origin.
Gastric antral vascular ectasia (GAVE) is an uncommon cause of chronic gastrointestinal bleeding or iron deficiency anemia. [1] [2] The condition is associated with dilated small blood vessels in the gastric antrum, which is a distal part of the stomach. [1]
[1] [8] Endoscopy, a type of X-ray known as an upper gastrointestinal series, blood tests, and stool tests may help with diagnosis. [1] Other conditions with similar symptoms include inflammation of the pancreas, gallbladder problems, and peptic ulcer disease. [2] Prevention is by avoiding things that cause the disease.
Pernicious anemia: D51.0: 9870: Pernicious anemia (also known as macrocytic achylic anemia, congenital pernicious anemia, juvenile pernicious anemia, and Vitamin B12 deficiency) is one of many types of the larger family of megaloblastic anemias. It is caused by loss of gastric parietal cells, and subsequent inability to absorb vitamin B 12.
This may also be due to the autoimmune attack on the parietal cells of the stomach in pernicious anemia. There is an association with gastric antral vascular ectasia (which can be referred to as watermelon stomach), and pernicious anemia. [32] Neurological symptoms: sensory or motor deficiencies (absent reflexes, diminished vibration or soft ...
Before iron deficiency anemia sets in, “the body will do everything it can to retain the right number of red blood cells. So, it will deplete the storage iron before it depletes the red blood ...
A long-term deficiency in vitamin B 12 can lead to megaloblastic anemia, characterized by large fragile red blood cells. Pernicious anaemia results from autoimmune destruction of gastric parietal cells, precluding the synthesis of intrinsic factor and, by extension, absorption of vitamin B 12. Pernicious anemia also leads to megaloblastic anemia.
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