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p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates , where they prevent cancer formation. [ 5 ]
Embryoid body: hESCs in culture spontaneously form ball-like embryo-like structures termed "embryoid bodies", which consist of a core of mitotically active and differentiating hESCs and a periphery of fully differentiated cells from all three germ layers. iPSCs also form embryoid bodies and have peripheral differentiated cells.
For example ESCs have been differentiated into insulin-producing cells, [26] and researchers at Harvard University were able to produce large quantities of pancreatic beta cells from ESCs. [ 27 ] An article published in the European Heart Journal describes a translational process of generating human embryonic stem cell-derived cardiac ...
The p53 p63 p73 family is a family of tumor suppressor genes. [1] [2] This gene family codes the proteins: p53; TP73L (also known as "p63") p73; They are sometimes considered part of a "p53 family." When overexpressed, these proteins are known to be involved in tumor pathogenesis. [3]
At the intracellular level, hECTs exhibit several essential structural features of cardiomyocytes, including organized sarcomeres, gap-junctions, and sarcoplasmic reticulum structures; [1] however, the distribution and organization of many of these structures is characteristic of neonatal heart tissue rather than adult human heart muscle.
Mutated p53 is also involved in the pathophysiology of leukemias, lymphomas, sarcomas, and neurogenic tumors. Abnormalities of the p53 gene can be inherited in Li-Fraumeni syndrome (LFS), which increases the risk of developing various types of cancers. BCL2. BCL2 is a family of proteins that are involved in either inducing or inhibiting ...
The remaining five Australians from the infamous “Bali Nine” drug gang are “relieved and happy” to be home after Canberra struck a deal with Jakarta to end their two decades of imprisonment.
It cooperates with p53 to induce the activation of p53 target genes, thus activating cell-cycle checkpoints. [ 12 ] p53 itself is an important tumor-suppressor gene sometimes known by the epithet “the guardian of the genome.” hnRNP K’s close association with p53 demonstrates its importance in DNA damage control.