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The Common Terminology Criteria for Adverse Events (CTCAE), [1] formerly called the Common Toxicity Criteria (CTC or NCI-CTC), are a set of criteria for the standardized classification of adverse events of drugs and treatment used in cancer therapy. The CTCAE system is a product of the US National Cancer Institute (NCI).
In addition, toxicity categories may be used for regulatory purposes other than labeling, such as classification for restricted use and requirements for child-resistant packaging. In certain cases, statements based upon the Toxicity Category of the product as diluted for use are also permitted. A Toxicity Category is assigned for each of five ...
Toxicity class refers to a classification system for pesticides that has been created by a national or international government-related or -sponsored organization. It addresses the acute toxicity of agents such as soil fumigants , fungicides , herbicides , insecticides , miticides , molluscicides , nematicides , or rodenticides .
Grades Toxicity Grade 1: Mild reaction, infusion interruption not indicated; intervention not indicated Grade 2: Therapy or infusion interruption indicated but responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics, IV fluids); prophylactic medications indicated for <=24 hrs Grade 3
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. [1] Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell (cytotoxicity) or an organ such as the liver (hepatotoxicity).
Acute toxicity describes the adverse effects of a substance that result either from a single exposure [1] or from multiple exposures in a short period of time (usually less than 24 hours). [ 2 ] To be described as acute toxicity, the adverse effects should occur within 14 days of the administration of the substance.
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The pictogram for harmful substances of the Globally Harmonized System of Classification and Labelling of Chemicals.. The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) is an internationally agreed-upon standard managed by the United Nations that was set up to replace the assortment of hazardous material classification and labelling schemes previously used around ...