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Similarly, the same sequences in the fugu genome have 68% identity to human UCEs, despite the human genome only reliably aligning to 1.8% of the fugu genome. [4] Despite often being noncoding DNA, [6] some ultraconserved elements have been found to be transcriptionally active, producing non-coding RNA molecules. [7]
UCbase is a database of ultraconserved sequences (UCRs or UCEs) that were first described by Bejerano, G. et al. [2] in 2004. They are highly conserved genome regions that share 100% identity among human, mouse and rat. UCRs are 481 sequences longer than 200 bases.
Within a sequence, amino acids that are important for folding, structural stability, or that form a binding site may be more highly conserved. [17] [18] The nucleic acid sequence of a protein coding gene may also be conserved by other selective pressures. The codon usage bias in some organisms may restrict the types of synonymous mutations in a ...
A conserved non-coding sequence (CNS) is a DNA sequence of noncoding DNA that is evolutionarily conserved. These sequences are of interest for their potential to regulate gene production. [1] CNSs in plants [2] and animals [1] are highly associated with transcription factor binding sites and other cis-acting regulatory elements.
The term "repeated sequence" was first used by Roy John Britten and D. E. Kohne in 1968; they found out that more than half of the eukaryotic genomes were repetitive DNA through their experiments on reassociation of DNA. [5] Although the repetitive DNA sequences were conserved and ubiquitous, their biological role was yet unknown.
Introns are intervening sequences between the exons that are never translated. Some sequences inside introns function as miRNA, and there are even some cases of small genes residing completely within the intron of a large gene. For some genes (such as the antibody genes), internal control regions are found inside introns. These situations ...
A study published last year found that a healthy diet could increase lifespan by up to 10 years, and Nathan K. LeBrasseur, a physiologist at Mayo Clinic, previously told BI that spending just 3% ...
Sequence comparison of msDNAs from Myxococcus xanthus, Stigmatella aurantiaca, [1] and many other bacteria [5] [12] reveal conserved and hypervariable domains reminiscent of conserved and hypervariable sequences found in allorecognition molecules. [13]