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Genetic theories of aging propose that aging is programmed within each individual's genes. According to this theory, genes dictate cellular longevity. Programmed cell death, or apoptosis , is determined by a "biological clock" via genetic information in the nucleus of the cell.
The DNA damage theory of aging postulates that DNA damage is ubiquitous in the biological world and is the primary cause of ageing. [27] The theory is based on the idea that ageing occurs over time due to the damage of the DNA.
Ageing (or aging in American English) is the process of becoming older. The term refers mainly to humans , many other animals , and fungi, whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal . [ 1 ]
Biological aging explained "Chronological age is what the calendar tells us," Elissa Epel, PhD, a professor in the department of psychiatry & behavioral sciences at the University of California ...
Theories of biological aging; A. Aging by design theory; Aging theories based on evolvability; Aging theories based on group selection; Antagonistic pleiotropy ...
Senescence (/ s ɪ ˈ n ɛ s ə n s /) or biological aging is the gradual deterioration of functional characteristics in living organisms. Whole organism senescence involves an increase in death rates or a decrease in fecundity with increasing age, at least in the later part of an organism's life cycle.
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. The hallmarks of aging are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death.
The metabolic stability theory of aging suggests it is the cells ability to maintain stable concentration of ROS which is the primary determinant of lifespan. [37] This theory criticizes the free radical theory because it ignores that ROS are specific signalling molecules which are necessary for maintaining normal cell functions. [37]