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The two theories; non-adaptive, and adaptive, are used to explain the evolution of senescence, which is the decline in reproduction with age. [8] The non-adaptive theory assumes that the evolutionary deterioration of human age occurs as a result of accumulation of deleterious mutations in the germline. [8]
The theory that DNA damage is the primary cause of aging is based, in part, on evidence in human and mouse that inherited deficiencies in DNA repair genes often cause accelerated aging. [ 29 ] [ 30 ] [ 27 ] There is also substantial evidence that DNA damage accumulates with age in mammalian tissues, such as those of the brain, muscle, liver and ...
The DNA damage theory of aging proposes that aging is a consequence of unrepaired accumulation of naturally occurring DNA damage. Damage in this context is a DNA alteration that has an abnormal structure. Although both mitochondrial and nuclear DNA damage can contribute to aging, nuclear DNA is the main subject of this analysis.
Biological aging explained "Chronological age is what the calendar tells us," Elissa Epel, PhD, a professor in the department of psychiatry & behavioral sciences at the University of California ...
Senescence (/ s ɪ ˈ n ɛ s ə n s /) or biological aging is the gradual deterioration of functional characteristics in living organisms. Whole organism senescence involves an increase in death rates or a decrease in fecundity with increasing age, at least in the later part of an organism's life cycle.
Pages in category "Theories of biological ageing" The following 30 pages are in this category, out of 30 total. ... Aging theories based on evolvability;
Theories of non-biological ageing (4 P) Pages in category "Theories of ageing" The following 31 pages are in this category, out of 31 total. ... Aging theories based ...
Ageing (or aging in American English) is the process of becoming older. The term refers mainly to humans , many other animals , and fungi, whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal . [ 1 ]