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  2. Diagnosis of multiple sclerosis - Wikipedia

    en.wikipedia.org/.../Diagnosis_of_multiple_sclerosis

    Current standards for diagnosing multiple sclerosis (MS) are based on the 2018 revision of McDonald criteria.They rely on MRI detection (or clinical demonstration) of demyelinating lesions in the CNS, which are distributed in space (DIS) and in time (DIT).

  3. Lesional demyelinations of the central nervous system

    en.wikipedia.org/wiki/Lesional_demyelinations_of...

    Normally MS lesions are small ovoid lesions, less than 2 cm. long, oriented perpendicular to the long axis of the brain's ventricles [18] Often they are disposed surrounding a vein [19] Demyelinization by MS. The Klüver-Barrera colored tissue show a clear decoloration in the area of the lesion (Original scale 1:100)

  4. Signs and symptoms of multiple sclerosis - Wikipedia

    en.wikipedia.org/wiki/Signs_and_symptoms_of...

    At five year follow-ups the overall risk of developing MS is 30%, with or without MRI lesions. Patients with a normal MRI still develop MS (16%), but at a lower rate compared to those patients with three or more MRI lesions (51%). From the other perspective, however, 44% of patients with any demyelinating lesions on MRI at presentation will not ...

  5. Multiple sclerosis - Wikipedia

    en.wikipedia.org/wiki/Multiple_sclerosis

    Animation showing dissemination of brain lesions in time and space as demonstrated by monthly MRI studies along a year Multiple sclerosis as seen on MRI. Multiple sclerosis is typically diagnosed based on the presenting signs and symptoms, in combination with supporting medical imaging and laboratory testing. [5]

  6. Radiologically isolated syndrome - Wikipedia

    en.wikipedia.org/wiki/Radiologically_isolated...

    The nerve lesions in these people show dissemination in space with an otherwise normal neurological examination and without historical accounts of typical MS symptoms. [1] MRI findings that are consistent with multiple sclerosis have been observed in healthy people who underwent MRI scanning, and 50% go on to develop symptomatic MS, sometimes ...

  7. Tumefactive multiple sclerosis - Wikipedia

    en.wikipedia.org/wiki/Tumefactive_multiple_sclerosis

    Tumefactive multiple sclerosis is a condition in which the central nervous system of a person has multiple demyelinating lesions with atypical characteristics for those of standard multiple sclerosis (MS). It is called tumefactive as the lesions are "tumor-like" and they mimic tumors clinically, radiologically and sometimes pathologically.

  8. Pathology of multiple sclerosis - Wikipedia

    en.wikipedia.org/.../Pathology_of_multiple_sclerosis

    Drawing of sclerotic lesions from Babinski's thesis "Etude anatomique et clinique de la sclérose en plaques", 1885. Multiple sclerosis (MS) can be pathologically defined as the presence of distributed glial scars in the central nervous system that must show dissemination in time (DIT) and in space (DIS) to be considered MS lesions.

  9. McDonald criteria - Wikipedia

    en.wikipedia.org/wiki/McDonald_criteria

    The McDonald criteria maintained a scheme for diagnosing MS based solely on clinical grounds but also proposed for the first time that when clinical evidence is lacking, magnetic resonance imaging (MRI) findings can serve as surrogates for dissemination in space (DIS) and/or time (DIT) to diagnose MS. [5] The criteria try to prove the existence ...

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