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  2. Pegunigalsidase alfa - Wikipedia

    en.wikipedia.org/wiki/Pegunigalsidase_alfa

    Pegunigalsidase alfa, sold under the brand name Elfabrio, is an enzyme replacement therapy for the treatment of Fabry disease. [2] [4] It is a recombinant human α-galactosidase-A. [4] It is a hydrolytic lysosomal neutral glycosphingolipid-specific enzyme. [2] The most common side effects are infusion-related reactions, hypersensitivity and ...

  3. α-Galactosidase - Wikipedia

    en.wikipedia.org/wiki/Α-Galactosidase

    α-Galactosidase ( EC 3.2.1.22, α-GAL, α-GAL A; systematic name α-D-galactoside galactohydrolase) is a glycoside hydrolase enzyme that catalyses the following reaction: [1] Hydrolysis of terminal, non-reducing α- D -galactose residues in α- D -galactosides, including galactose oligosaccharides, galactomannans and galactolipids

  4. GLA (gene) - Wikipedia

    en.wikipedia.org/wiki/GLA_(gene)

    Two recombinant enzyme replacement therapies are available to functionally compensate for α-galactosidase deficiency. Agalsidase α and β are both recombinant forms of the human α-galactosidase A enzyme and both have the same amino acid sequence as the native enzyme. Agalsidase α and β differ in the structures of their oligosaccharide side ...

  5. Expert Trainer Explains Why Dogs Growl & How to Handle It - AOL

    www.aol.com/expert-trainer-explains-why-dogs...

    Medication Side Effects. When dogs undergo surgery, they are often provided with pain medications and anti-inflammatory drugs to ease the pain and inflammation. Some of these drugs can cause side ...

  6. Alglucosidase alfa - Wikipedia

    en.wikipedia.org/wiki/Alglucosidase_alfa

    Alglucosidase alfa, sold under the brand name Myozyme among others, is an enzyme replacement therapy (ERT) orphan drug for treatment of Pompe disease (Glycogen storage disease type II), a rare lysosomal storage disorder (LSD). [6] Chemically, the drug is an analog of the enzyme that is deficient in patients affected by Pompe disease, alpha ...

  7. Galactosidases - Wikipedia

    en.wikipedia.org/wiki/Galactosidases

    Galactosidases are enzymes (glycoside hydrolases) that catalyze the hydrolysis of galactosides into monosaccharides.. Galactosides can be classified as either alpha or beta. If the galactoside is classified as an alpha-galactoside, the enzyme is called alpha-galactosidase, and is responsible for catalyzing the hydrolysis of substrates that contain α-galactosidic residues, such as ...

  8. Fabry disease - Wikipedia

    en.wikipedia.org/wiki/Fabry_disease

    A person who inherits this gene does not have enough of a functioning enzyme known as alpha-galactosidase A. The lack of alpha-galactosidase leads to Fabry disease. A deficiency of alpha galactosidase A (a-GAL A, encoded by GLA) due to mutation causes a glycolipid known as globotriaosylceramide (abbreviated as Gb3, GL-3, or ceramide trihexoside ...

  9. Cushing's syndrome (veterinary) - Wikipedia

    en.wikipedia.org/wiki/Cushing's_syndrome...

    Disadvantages of mitotane as a treatment include the side effects and the requirement for blood test monitoring. Issues can arise when too much of the adrenal cortex becomes eroded. Approximately 30% of dogs will experience a reaction in response to treatment with mitotane; prednisone may be used as an antidote. In the event of a reaction ...

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