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Cellular senescence is a phenomenon characterized by ... SASPs have distinct effects depending on the cellular context, including inflammatory or anti-inflammatory ...
Senescent cell populations increase with age and secrete a pro-inflammatory cocktail of chemicals, a condition known as senescence-associated secretory phenotype (SASP). [14] Cells with the SASP are characterized by being in cell cycle arrest, releasing inflammatory factors, and possessing a particular morphology.
This is called cellular senescence. Senescence can be induced by several factors, including telomere shortening, [37] DNA damage [38] and stress. Since the immune system is programmed to seek out and eliminate senescent cells, [39] it might be that senescence is one way for the body to rid itself of cells damaged beyond repair.
It is in line with the 12 hallmarks of aging, such as chronic inflammation and cellular senescence, that happen on a molecular level as people grow older. It also explains how older adults ...
But some SASP components are anti-inflammatory. [11] Senescence and SASP can also occur in post-mitotic cells, notably neurons. [12] The SASP in senescent neurons can vary according to cell type, the initiator of senescence, and the stage of senescence. [12] An online SASP Atlas serves as a guide to the various types of SASP. [8]
Senescence (/ s ɪ ˈ n ɛ s ə n s /) or biological aging is the gradual deterioration of functional characteristics in living organisms. Whole organism senescence involves an increase in death rates or a decrease in fecundity with increasing age, at least in the later part of an organism's life cycle.
Aging of the immune system is a controversial phenomenon. Senescence refers to replicative senescence from cell biology, which describes the condition when the upper limit of cell divisions (Hayflick limit) has been exceeded, and such cells commit apoptosis or lose their functional properties.
The cGAS–STING pathway is a component of the innate immune system that functions to detect the presence of cytosolic DNA and, in response, trigger expression of inflammatory genes that can lead to senescence [1] or to the activation of defense mechanisms. DNA is normally found in the nucleus of the cell.
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