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The Draize test is an acute toxicity test devised in 1944 by Food and Drug Administration (FDA) toxicologists John H. Draize and Jacob M. Spines. Initially used for testing cosmetics, the procedure involves applying 0.5 mL or 0.5 g of a test substance to the eye or skin of a restrained, conscious animal, and then leaving it for a set amount of time before rinsing it out and recording its effects.
Lugol's solution is commonly available in different potencies of (nominal) 1%, 2%, 5% or 10%. Iodine concentrations greater than 2.2% are subject to US regulations. [11] [33] [34] If the US regulations are taken literally, their 2.2% maximum iodine concentration limits a Lugol's solution to maximum (nominal) 0.87%.
For example, 0.4 oz (11 g) of baker's chocolate would be enough to produce mild symptoms in a 20 lb (9.1 kg) dog, while a 25% cacao chocolate bar (like milk chocolate) would be only 25% as toxic as the same dose of baker's chocolate. [15] One ounce of milk chocolate per pound of body weight (63 g/kg) is a potentially lethal dose in dogs. [14]
As little as 10 mL of pure methanol when drunk is metabolized into formic acid, which can cause permanent blindness by destruction of the optic nerve. 15 mL is potentially fatal, [1] although the median lethal dose is typically 100 mL (3.4 fl oz) (i.e. 1–2 mL/kg body weight of pure methanol). [4] Reference dose for methanol is 0.5 mg/kg/day. [9]
The minim was defined as one 60th of a fluid dram or one 480th of a fluid ounce. [4] This is equal to about 61.6 μL (U.S.) or 59.2 μL (Britain). Pharmacists have since moved to metric measurements, with a drop being rounded to exactly 0.05 mL (50 μL, that is, 20 drops per milliliter).
You can find instant answers on our AOL Mail help page. Should you need additional assistance we have experts available around the clock at 800-730-2563. Should you need additional assistance we have experts available around the clock at 800-730-2563.
Unopened dry dog food may last from 12 to 18 months, but once opened it may only be good for as little as two to six weeks. Check the expiry date to be sure.
One ounce (oz) of milk chocolate contains 44 - 55 milligrams (mg) of theobromine, and baker's chocolate contains 393 mg of theobromine. [38] The lethal dose for 50% of dogs ( LD50 ) is 100 – 200 mg per kilogram (kg) of body weight, yet some dogs will exhibit signs of toxicosis after ingesting as little as 20 mg per kg. [ 38 ]